What About Vallovax TM

Stimulating a multi-faceted immune response against cancer’s Achilles heel: the tumor endothelium

Batu Biologies has developed a novel approach to fighting cancer through vaccines and immune stimulation. Its core
product ValloVax,M is a cellular anti-angiogenic cancer vaccine designed to stimulate an immune response against the tumor endothelium for the initial condition of lung cancer. ValloVax
targets multiple proteins found on the tumor-associated blood vessels and seeks to target and prevent tumor angiogenesis.

Why is the Tumor Endothelium
the target of Vallovax TM

No mutation means that the blood vessels around the tumor do not develop drug resistance.

Without angiogenesis, or the formation of new blood vessels, the tumor cannot exceed 1 to 2 mm in diameter.

The tumor endothelium is in direct contact with the body’s immune system, addressing the issue of drug delivery to
hypoxic areas of the tumor.

The diagram below was published in the journal, Oncotarget, and describes the mechanism of
action of the ValloVax induced immune Response :

Technical Solutions

Current angiogenesis inhibitors, such as Avastin. target only one of the key pathways of angiogenesis (VEGF). In contrast, ValloVax™
stimulates the immune system to attack multiple pathways necessary for angiogenesis, thus having the potential for superior efficacy and specificity in comparison with existing drugs. ValloVaxIM is differentiated from current anti-angiogenic therapies because it stimulates the direct immune system killing of the tumor endothelium while existing tyrosine-kinase inhibitors merely block the VEGF pathway – slowing the angiogenic
process at best.

Batu Biologies has developed the vaccine and proprietary extraction system and has filed several patents in the field of
immunothereputic cancer vaccines. The company is in the process of filing its 28th provisional patent in the fieldof cancer immunotherapy. Batu’s strategy is focused on preparing ValloVax™ to enter Phase I clinical trials.

Batu Biologies is targeting non small cell lung cancer (NSCLC) as the first treatment indication for ValloVax™, with expanded indications to follow. Currently. Batu Biologies is seeking to complete the development and characterization of ValloVax'”, completing the pre-clinical
testing and preparing and filing an Investigational New Drug (iND) application in anticipation of a Phase I clinical trial for advanced lung cancer. Batu Biologies will continue to optimize the value of its technologies through IP expansion, license opportunities, and co-
development of secondary treatment indications.

With the recent successes of immunotherapy in a variety of tumors, Batu Biologies believes there is an increasing unmet need for non-toxic immune modulators that can augment efficacy of existing therapeutics. Our Team is motivated to bring novel therapeutics to the forefront of medical research that use the power of the body’s own immune system to extend life expectancy.

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